You should create an organizational unit (OU) specifically for your remote desktops. An OU is a subdivision in Active Directory that contains users, groups, computers, or other OUs.
To prevent group policy settings from being applied to other Windows servers or workstations in the same domain as your desktops, you can create a GPO for your Omnissa Horizon 8 group policies and link it to the OU that contains your remote desktops. You can also delegate control of the OU to subordinate groups, such as server operators or individual users.
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